10.1021/ja055752d.s001 Michael A. Calter Michael A. Calter Ryan M. Phillips Ryan M. Phillips Christine Flaschenriem Christine Flaschenriem Catalytic, Asymmetric, “Interrupted” Feist−Bénary Reactions American Chemical Society 2005 Feist cinchona alkaloids function hydrobromide salt unsubstituted bromoketones Interrupted catalyst Mechanistic experiments 2005-10-26 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Catalytic_Asymmetric_Interrupted_Feist_B_nary_Reactions/3261373 Pyrimidine derivatives of the cinchona alkaloids function as excellent asymmetric catalysts for the “Interrupted” Feist−Bénary Reaction. This reaction produces highly substituted hydroxydihydrofurans from simple starting materials under mild conditions. The asymmetric reaction gives high enantioselectivities with unsubstituted bromoketones, and high enantio- and diastereoselectivities with substituted substrates. Mechanistic experiments suggest that the hydrobromide salt of the alkaloid derivative is the active catalyst for the reaction.