10.1021/jm0507330.s001 Sara Bartolini Sara Bartolini Antonello Mai Antonello Mai Marino Artico Marino Artico Nicola Paesano Nicola Paesano Dante Rotili Dante Rotili Corrado Spadafora Corrado Spadafora Gianluca Sbardella Gianluca Sbardella 6-[1-(2,6-Difluorophenyl)ethyl]pyrimidinones Antagonize Cell Proliferation and Induce Cell Differentiation by Inhibiting (a Nontelomeric) Endogenous Reverse Transcriptase American Chemical Society 2005 Induce Cell Differentiation differentiation cell proliferation antiproliferative drugs cell systems tumor therapy dedifferentiating pathologies DABO MC F 2 cytodifferentiating activity 2005-11-03 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/6_1_2_6_Difluorophenyl_ethyl_pyrimidinones_Antagonize_Cell_Proliferation_and_Induce_Cell_Differentiation_by_Inhibiting_a_Nontelomeric_Endogenous_Reverse_Transcriptase/3259087 Two 2,6-difluoro-DABO derivatives (MC 1047, <b>1</b>, and MC 1220, <b>2</b>, respectively) were tested against endogenous, nontelomeric reverse transcriptase (endo-RT) in human differentiating cell systems to investigate their antiproliferative and cytodifferentiating activity. The two compounds significantly reduced cell proliferation and facilitated the morphological differentiation of cells. These results propose F<sub>2</sub>-DABOs as useful tools in preventive and/or curative therapy to counteract the loss of differentiation in dedifferentiating pathologies and as antiproliferative drugs in tumor therapy.