10.1021/jm0507330.s001
Sara Bartolini
Sara
Bartolini
Antonello Mai
Antonello
Mai
Marino Artico
Marino
Artico
Nicola Paesano
Nicola
Paesano
Dante Rotili
Dante
Rotili
Corrado Spadafora
Corrado
Spadafora
Gianluca Sbardella
Gianluca
Sbardella
6-[1-(2,6-Difluorophenyl)ethyl]pyrimidinones Antagonize Cell Proliferation
and Induce Cell Differentiation by
Inhibiting (a Nontelomeric) Endogenous
Reverse Transcriptase
American Chemical Society
2005
Induce Cell Differentiation
differentiation
cell proliferation
antiproliferative drugs
cell systems
tumor therapy
dedifferentiating pathologies
DABO
MC
F 2
cytodifferentiating activity
2005-11-03 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/6_1_2_6_Difluorophenyl_ethyl_pyrimidinones_Antagonize_Cell_Proliferation_and_Induce_Cell_Differentiation_by_Inhibiting_a_Nontelomeric_Endogenous_Reverse_Transcriptase/3259087
Two 2,6-difluoro-DABO derivatives (MC 1047, <b>1</b>,
and MC 1220, <b>2</b>, respectively) were tested against endogenous,
nontelomeric reverse transcriptase (endo-RT) in human differentiating cell systems to investigate their antiproliferative
and cytodifferentiating activity. The two compounds significantly reduced cell proliferation and facilitated the morphological differentiation of cells. These results propose F<sub>2</sub>-DABOs
as useful tools in preventive and/or curative therapy to
counteract the loss of differentiation in dedifferentiating
pathologies and as antiproliferative drugs in tumor therapy.