10.1021/jm050723z.s001 Conrad W. Hummel Conrad W. Hummel Andrew G. Geiser Andrew G. Geiser Henry U. Bryant Henry U. Bryant Ilene R. Cohen Ilene R. Cohen Robert D. Dally Robert D. Dally Kin Chiu Fong Kin Chiu Fong Scott A. Frank Scott A. Frank Ronald Hinklin Ronald Hinklin Scott A. Jones Scott A. Jones George Lewis George Lewis Denis J. McCann Denis J. McCann Daniel G. Rudmann Daniel G. Rudmann Timothy A. Shepherd Timothy A. Shepherd Hongqi Tian Hongqi Tian Owen B. Wallace Owen B. Wallace Minmin Wang Minmin Wang Yong Wang Yong Wang Jeffrey A. Dodge Jeffrey A. Dodge A Selective Estrogen Receptor Modulator Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats American Chemical Society 2005 uterine leiomyoma ER α SERM uterine antagonist estrogen receptor modulator affinity histologic evaluation Uteru Uterine Leiomyoma Ovarie estrogen receptors α serum biomarkers Unique Tissue Specificity Rats Selective Estrogen Receptor Modulator ovarie LY 2005-11-03 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/A_Selective_Estrogen_Receptor_Modulator_Designed_for_the_Treatment_of_Uterine_Leiomyoma_with_Unique_Tissue_Specificity_for_Uterus_and_Ovaries_in_Rats/3259084 The design of a novel selective estrogen receptor modulator (SERM) for the potential treatment of uterine leiomyoma is described. <b>16</b> (LY2066948−HCl) binds with high affinity to estrogen receptors α and β (ERα and ERβ, respectively) and is a potent uterine antagonist with minimal effects on the ovaries as determined by serum biomarkers and histologic evaluation.