Dragmacidin E Synthesis Studies. Preparation of a Model Cycloheptannelated Indole Fragment FeldmanKen S. NgernmeesriPaiboon 2005 The conversion of <i>N</i>-2,2-dichloropropionyl indole methyl ester into a tetracyclic cycloheptannelated indole model compound for the synthesis of dragmacidin E was accomplished in 10 steps. Key reactions include a Witkop cyclization to fashion a C−C bond at C(4) of the indole nucleus and a subsequent Dieckmann cyclization to deliver the desired cycloheptanoid ring.