%0 Journal Article %A Feldman, Ken S. %A Ngernmeesri, Paiboon %D 2005 %T Dragmacidin E Synthesis Studies. Preparation of a Model Cycloheptannelated Indole Fragment %U https://acs.figshare.com/articles/journal_contribution/Dragmacidin_E_Synthesis_Studies_Preparation_of_a_Model_Cycloheptannelated_Indole_Fragment/3255538 %R 10.1021/ol0522081.s001 %2 https://acs.figshare.com/ndownloader/files/5090917 %K Dragmacidin E Synthesis Studies %K Witkop cyclization %K Key reactions %K indole nucleus %K dragmacidin E %K 10 steps %K Model Cycloheptannelated Indole Fragment %K Dieckmann cyclization %K cycloheptanoid ring %K tetracyclic cycloheptannelated indole model compound %X The conversion of N-2,2-dichloropropionyl indole methyl ester into a tetracyclic cycloheptannelated indole model compound for the synthesis of dragmacidin E was accomplished in 10 steps. Key reactions include a Witkop cyclization to fashion a C−C bond at C(4) of the indole nucleus and a subsequent Dieckmann cyclization to deliver the desired cycloheptanoid ring. %I ACS Publications