%0 Journal Article %A Liu, Yu %A Liang, Peng %A Chen, Yong %A Zhao, Yan-Li %A Ding, Fei %A Yu, Ao %D 2005 %T Spectrophotometric Study of Fluorescence Sensing and Selective Binding of Biochemical Substrates by 2,2‘-Bridged Bis(β-cyclodextrin) and Its Water-Soluble Fullerene Conjugate %U https://acs.figshare.com/articles/journal_contribution/Spectrophotometric_Study_of_Fluorescence_Sensing_and_Selective_Binding_of_Biochemical_Substrates_by_2_2_Bridged_Bis_i_i_cyclodextrin_and_Its_Water_Soluble_Fullerene_Conjugate/3251392 %R 10.1021/jp0527507.s001 %2 https://acs.figshare.com/ndownloader/files/5086762 %K Spectrophotometric Study %K UV %K Spectrophotomeric studies %K hydroxyl side %K Selective Binding %K dichroism spectroscopy %K fluorescence sensor %K cleaving DNA %K inclusion complexation behavior %K fullerene conjugate 3 displays %K cyclodextrin %K conformation %K precursor N %K bi %K Biochemical Substrates %K substrate %K NMR %X A bis(β-cyclodextrin)−fullerene conjugate (3) linked at the secondary hydroxyl side was prepared in a good yield from its precursor N,N‘-bis(2-(2-aminoethylamino)ethyl)malonamide-bridged bis(β-cyclodextrin) (2). Spectrophotomeric studies on the conformation and the inclusion complexation behavior of 3 with a variety of organic and biochemical substrates by means of UV−vis, FT-IR, NMR, fluorescence, and circular dichroism spectroscopy showed that the bis(β-cyclodextrin)−fullerene conjugate displayed an intramolecular capsule-type conformation in aqueous solution. Because of the multiple binding of bis(β-cyclodextrin) with substrates, 2 can act as an efficient fluorescence sensor for biochemical substrates, while its fullerene conjugate 3 displays a capability of cleaving DNA under visible-light irradiation. %I ACS Publications