10.1021/jo051854a.s001 David M. Bartley David M. Bartley James K. Coward James K. Coward Regioselective Synthesis of α-Methyl 2-Methyleneglutarate via a Novel Lactonization−Elimination Rearrangement American Chemical Society 2006 hydroxymethyl sequence Regioselective formation diester precursor proceeds Methyl Regioselective Synthesis Methyleneglutarate deprotection methyl Lactonization methyleneglutarate tandem silyl Rearrangement hydroxymethylcyclopentene monoacid 2006-01-06 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Regioselective_Synthesis_of_Methyl_2_Methyleneglutarate_via_a_Novel_Lactonization_Elimination_Rearrangement/3245281 A facile route to the α-methyl ester of 2-methyleneglutarate via a three-step sequence from 3-hydroxymethylcyclopentene is described. Regioselective formation of the monoacid from a diester precursor proceeds via a novel fluoride-mediated, tandem deprotection/rearrangement of <i>O</i>-silyl 2-(hydroxymethyl)dimethylglutarate.