A New Modular Indole Synthesis.
Construction of the Highly Strained
CDEF Parent Tetracycle of Nodulisporic
Acids A and B
Amos B. Smith
László Kürti
Akin H. Davulcu
10.1021/ol0606536.s001
https://acs.figshare.com/articles/journal_contribution/A_New_Modular_Indole_Synthesis_Construction_of_the_Highly_Strained_CDEF_Parent_Tetracycle_of_Nodulisporic_Acids_A_and_B/3223288
Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic
acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald−Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted
indoles possessing uncommon substitution patterns.
2006-05-11 00:00:00
Construction
indole synthesis
New Modular Indole Synthesis
CDEF parent tetracycle
Strained CDEF Parent Tetracycle