A New Modular Indole Synthesis. Construction of the Highly Strained CDEF Parent Tetracycle of Nodulisporic Acids A and B Amos B. Smith László Kürti Akin H. Davulcu 10.1021/ol0606536.s001 https://acs.figshare.com/articles/journal_contribution/A_New_Modular_Indole_Synthesis_Construction_of_the_Highly_Strained_CDEF_Parent_Tetracycle_of_Nodulisporic_Acids_A_and_B/3223288 Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald−Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns. 2006-05-11 00:00:00 Construction indole synthesis New Modular Indole Synthesis CDEF parent tetracycle Strained CDEF Parent Tetracycle