%0 Generic %A Smith, Amos B. %A Kürti, László %A Davulcu, Akin H. %D 2006 %T A New Modular Indole Synthesis. Construction of the Highly Strained CDEF Parent Tetracycle of Nodulisporic Acids A and B %U https://acs.figshare.com/articles/dataset/A_New_Modular_Indole_Synthesis_Construction_of_the_Highly_Strained_CDEF_Parent_Tetracycle_of_Nodulisporic_Acids_A_and_B/3223285 %R 10.1021/ol0606536.s005 %2 https://acs.figshare.com/ndownloader/files/5057344 %K Construction %K indole synthesis %K New Modular Indole Synthesis %K CDEF parent tetracycle %K Strained CDEF Parent Tetracycle %X Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald−Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns. %I ACS Publications