%0 Journal Article %A Hsieh, Sheng-Ying %A Bode, Jeffrey W. %D 2016 %T Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones %U https://acs.figshare.com/articles/journal_contribution/Silicon_Amine_Reagents_for_the_Photocatalytic_Synthesis_of_Piperazines_from_Aldehydes_and_Ketones/3188005 %R 10.1021/acs.orglett.6b00722.s001 %2 https://acs.figshare.com/ndownloader/files/4989046 %K silicon Amine Reagents %K tin amine protocol %K aliphatic aldehydes %K Photocatalytic Synthesis %K piperazine %K SLAP reagents %K form N %K Ketones Silicon amine protocol %X Silicon amine protocol (SLAP) reagents for photocatalytic cross-coupling with aldehydes and ketones to form N-unprotected piperazines have been developed. This blue light promoted process tolerates a wide range of heteroaromatic, aromatic, and aliphatic aldehydes and structurally and stereochemically complex SLAP reagents. It provides a tin-free alternative to SnAP (tin amine protocol) reagents for the synthesis of substituted piperazines. %I ACS Publications