10.1021/acscatal.6b00793.s001
Bryan
J. Simmons
Bryan J.
Simmons
Nicholas A. Weires
Nicholas A.
Weires
Jacob E. Dander
Jacob E.
Dander
Neil K. Garg
Neil K.
Garg
Nickel-Catalyzed Alkylation of Amide Derivatives
American Chemical Society
2016
building blocks
ambient temperature
Amide derivatives
nonprecious metal catalysis
Alkylation
utility
synthesis
nanomolar glucagon receptor modulator
nature
nickel catalysis
methodology
Amide Derivatives
ketone products
alkylation
amide derivatives
variation
precursor
organozinc reagents
2016-04-12 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Nickel_Catalyzed_Alkylation_of_Amide_Derivatives/3181246
We report the catalytic alkylation
of amide derivatives, which
relies on the use of nonprecious metal catalysis. Amide derivatives
are treated with organozinc reagents, utilizing nickel catalysis,
to yield ketone products. The methodology is performed at ambient
temperature and is tolerant of variation in both coupling partners.
A precursor to a nanomolar glucagon receptor modulator was synthesized
using the methodology, underscoring the mild nature of this chemistry
and its potential utility in pharmaceutical synthesis. These studies
are expected to further promote the use of amides as synthetic building
blocks.