10.1021/acscatal.6b00793.s001 Bryan J. Simmons Bryan J. Simmons Nicholas A. Weires Nicholas A. Weires Jacob E. Dander Jacob E. Dander Neil K. Garg Neil K. Garg Nickel-Catalyzed Alkylation of Amide Derivatives American Chemical Society 2016 building blocks ambient temperature Amide derivatives nonprecious metal catalysis Alkylation utility synthesis nanomolar glucagon receptor modulator nature nickel catalysis methodology Amide Derivatives ketone products alkylation amide derivatives variation precursor organozinc reagents 2016-04-12 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Nickel_Catalyzed_Alkylation_of_Amide_Derivatives/3181246 We report the catalytic alkylation of amide derivatives, which relies on the use of nonprecious metal catalysis. Amide derivatives are treated with organozinc reagents, utilizing nickel catalysis, to yield ketone products. The methodology is performed at ambient temperature and is tolerant of variation in both coupling partners. A precursor to a nanomolar glucagon receptor modulator was synthesized using the methodology, underscoring the mild nature of this chemistry and its potential utility in pharmaceutical synthesis. These studies are expected to further promote the use of amides as synthetic building blocks.