%0 Generic
%A Kang, Tian-Shu
%A Mao, Zhifeng
%A Ng, Chan-Tat
%A Wang, Modi
%A Wang, Wanhe
%A Wang, Chunming
%A Lee, Simon
Ming-Yuen
%A Wang, Yitao
%A Leung, Chung-Hang
%A Ma, Dik-Lung
%D 2016
%T Identification of an Iridium(III)-Based Inhibitor
of Tumor Necrosis Factor‑α
%U https://acs.figshare.com/articles/dataset/Identification_of_an_Iridium_III_Based_Inhibitor_of_Tumor_Necrosis_Factor_/3179101
%R 10.1021/acs.jmedchem.6b00112.s002
%2 https://acs.figshare.com/ndownloader/files/4949251
%K NF
%K iridium enantiomers
%K bioactive metal
%K TNF
%K inhibitor
%X The
novel iridium(III) complex 1 was verified as a
potent inhibitor of the TNF-α–TNFR protein–protein
interaction in vitro and in cellulo. The
iridium(III) center plays a critical role in organizing the structure
of the bioactive metal complex, as the isolated ligands were found
to be completely inactive. Both iridium enantiomers inhibited TNF-α-induced
NF-κB activity and TNF-α–TNFR binding. 1 represents a promising scaffold for the further development of more
potent organometallic TNF-α inhibitors.
%I ACS Publications