%0 Generic %A Kang, Tian-Shu %A Mao, Zhifeng %A Ng, Chan-Tat %A Wang, Modi %A Wang, Wanhe %A Wang, Chunming %A Lee, Simon Ming-Yuen %A Wang, Yitao %A Leung, Chung-Hang %A Ma, Dik-Lung %D 2016 %T Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor‑α %U https://acs.figshare.com/articles/dataset/Identification_of_an_Iridium_III_Based_Inhibitor_of_Tumor_Necrosis_Factor_/3179101 %R 10.1021/acs.jmedchem.6b00112.s002 %2 https://acs.figshare.com/ndownloader/files/4949251 %K NF %K iridium enantiomers %K bioactive metal %K TNF %K inhibitor %X The novel iridium­(III) complex 1 was verified as a potent inhibitor of the TNF-α–TNFR protein–protein interaction in vitro and in cellulo. The iridium­(III) center plays a critical role in organizing the structure of the bioactive metal complex, as the isolated ligands were found to be completely inactive. Both iridium enantiomers inhibited TNF-α-induced NF-κB activity and TNF-α–TNFR binding. 1 represents a promising scaffold for the further development of more potent organometallic TNF-α inhibitors. %I ACS Publications