10.1021/acs.nanolett.6b00054.s001 Christina J. Newcomb Christina J. Newcomb Shantanu Sur Shantanu Sur Sungsoo S. Lee Sungsoo S. Lee Jeong Min Yu Jeong Min Yu Yan Zhou Yan Zhou Malcolm L. Snead Malcolm L. Snead Samuel I. Stupp Samuel I. Stupp Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility American Chemical Society 2016 Lipid Raft Mobility growth factor BMP -2 bone marrow stromal cells osteogenic growth factor Supramolecular Nanofibers Enhance Growth Factor Signaling membrane lipid rafts nanostructure 2016-04-12 16:18:40 Journal contribution https://acs.figshare.com/articles/journal_contribution/Supramolecular_Nanofibers_Enhance_Growth_Factor_Signaling_by_Increasing_Lipid_Raft_Mobility/3172201 The nanostructures of self-assembling biomaterials have been previously designed to tune the release of growth factors in order to optimize biological repair and regeneration. We report here on the discovery that weakly cohesive peptide nanostructures in terms of intermolecular hydrogen bonding, when combined with low concentrations of osteogenic growth factor, enhance both BMP-2 and Wnt mediated signaling in myoblasts and bone marrow stromal cells, respectively. Conversely, analogous nanostructures with enhanced levels of internal hydrogen bonding and cohesion lead to an overall reduction in BMP-2 signaling. We propose that the mechanism for enhanced growth factor signaling by the nanostructures is related to their ability to increase diffusion within membrane lipid rafts. The phenomenon reported here could lead to new nanomedicine strategies to mediate growth factor signaling for translational targets.