10.1021/acs.nanolett.6b00054.s001
Christina
J. Newcomb
Christina
J.
Newcomb
Shantanu Sur
Shantanu
Sur
Sungsoo S. Lee
Sungsoo S.
Lee
Jeong Min Yu
Jeong Min
Yu
Yan Zhou
Yan
Zhou
Malcolm L. Snead
Malcolm L.
Snead
Samuel I. Stupp
Samuel I.
Stupp
Supramolecular Nanofibers Enhance Growth Factor Signaling
by Increasing Lipid Raft Mobility
American Chemical Society
2016
Lipid Raft Mobility
growth factor
BMP -2
bone marrow stromal cells
osteogenic growth factor
Supramolecular Nanofibers Enhance Growth Factor Signaling
membrane lipid rafts
nanostructure
2016-04-12 16:18:40
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Supramolecular_Nanofibers_Enhance_Growth_Factor_Signaling_by_Increasing_Lipid_Raft_Mobility/3172201
The nanostructures
of self-assembling biomaterials have been previously designed to tune
the release of growth factors in order to optimize biological repair
and regeneration. We report here on the discovery that weakly cohesive
peptide nanostructures in terms of intermolecular hydrogen bonding,
when combined with low concentrations of osteogenic growth factor,
enhance both BMP-2 and Wnt mediated signaling in myoblasts and bone
marrow stromal cells, respectively. Conversely, analogous nanostructures
with enhanced levels of internal hydrogen bonding and cohesion lead
to an overall reduction in BMP-2 signaling. We propose that the mechanism
for enhanced growth factor signaling by the nanostructures is related
to their ability to increase diffusion within membrane lipid rafts.
The phenomenon reported here could lead to new nanomedicine strategies
to mediate growth factor signaling for translational targets.