Diastereoselective and Enantioselective Alleno-aldol
Reaction of Allenoates with Isatins to Synthesis of Carbinol Allenoates
Catalyzed by Gold
Gang Wang
Xiaohua Liu
Yushuang Chen
Jian Yang
Jun Li
Lili Lin
Xiaoming Feng
10.1021/acscatal.6b00294.s002
https://acs.figshare.com/articles/dataset/Diastereoselective_and_Enantioselective_Alleno_aldol_Reaction_of_Allenoates_with_Isatins_to_Synthesis_of_Carbinol_Allenoates_Catalyzed_by_Gold/3112831
A new
asymmetric alleno-aldol addition of allenic esters has been
developed that allows the formation of trisubstituted and tetrasubstituted
carbinol allenoates diastereoselectively and enantioselectively. The
nucleophilic additions of achiral and racemic allenates to isatins
proceed well in the presence of AuCl<sub>3</sub> and chiral <i>N</i>,<i>N</i>′-dioxide under mild reaction
conditions. The results reported herein represent the first example
of metal complex promoted γ-selective asymmetric addition of
allenic esters to carbonyl compounds.
2016-03-10 00:00:00
Carbinol Allenoates Catalyzed
allenic esters
tetrasubstituted carbinol allenoates diastereoselectively