%0 Generic %A More, Atul A. %A Ramana, Chepuri V. %D 2016 %T Total Synthesis of Integrastatin B Enabled by a Benzofuran Oxidative Dearomatization Cascade %U https://acs.figshare.com/articles/dataset/Total_Synthesis_of_Integrastatin_B_Enabled_by_a_Benzofuran_Oxidative_Dearomatization_Cascade/3085354 %R 10.1021/acs.orglett.6b00404.s002 %2 https://acs.figshare.com/ndownloader/files/4796971 %K integrastatin B %K tetracyclic nucleus %K dearomatization %K Integrastatin B Enabled %K HIV %K Benzofuran Oxidative Dearomatization Cascade %K benzofuran %K synthesis %K compound %K oxidative %K Total Synthesis %K integrase inhibitor %K cascade %X The first total synthesis of integrastatin B, a potent HIV-1 integrase inhibitor, has been accomplished in seven steps with a 17.9% overall yield employing easily accessible starting compounds. The Oxone-mediated oxidative benzofuran dearomatization cascade has been employed as the key skeletal construct to forge the central tetracyclic nucleus. %I ACS Publications