10.1021/acs.orglett.6b00404.s002 Atul A. More Atul A. More Chepuri V. Ramana Chepuri V. Ramana Total Synthesis of Integrastatin B Enabled by a Benzofuran Oxidative Dearomatization Cascade American Chemical Society 2016 integrastatin B tetracyclic nucleus dearomatization Integrastatin B Enabled HIV Benzofuran Oxidative Dearomatization Cascade benzofuran synthesis compound oxidative Total Synthesis integrase inhibitor cascade 2016-03-07 16:07:45 Dataset https://acs.figshare.com/articles/dataset/Total_Synthesis_of_Integrastatin_B_Enabled_by_a_Benzofuran_Oxidative_Dearomatization_Cascade/3085354 The first total synthesis of integrastatin B, a potent HIV-1 integrase inhibitor, has been accomplished in seven steps with a 17.9% overall yield employing easily accessible starting compounds. The Oxone-mediated oxidative benzofuran dearomatization cascade has been employed as the key skeletal construct to forge the central tetracyclic nucleus.