10.1021/acs.orglett.6b00404.s002
Atul A. More
Atul A.
More
Chepuri V. Ramana
Chepuri V.
Ramana
Total Synthesis of Integrastatin B Enabled by a Benzofuran
Oxidative Dearomatization Cascade
American Chemical Society
2016
integrastatin B
tetracyclic nucleus
dearomatization
Integrastatin B Enabled
HIV
Benzofuran Oxidative Dearomatization Cascade
benzofuran
synthesis
compound
oxidative
Total Synthesis
integrase inhibitor
cascade
2016-03-07 16:07:45
Dataset
https://acs.figshare.com/articles/dataset/Total_Synthesis_of_Integrastatin_B_Enabled_by_a_Benzofuran_Oxidative_Dearomatization_Cascade/3085354
The
first total synthesis of integrastatin B, a potent HIV-1 integrase
inhibitor, has been accomplished in seven steps with a 17.9% overall
yield employing easily accessible starting compounds. The Oxone-mediated
oxidative benzofuran dearomatization cascade has been employed as
the key skeletal construct to forge the central tetracyclic nucleus.