10.1021/np060087n.s002 Zhen Xue Zhen Xue Shuai Li Shuai Li Sujuan Wang Sujuan Wang Yinhong Wang Yinhong Wang Yongchun Yang Yongchun Yang Jiangong Shi Jiangong Shi Lan He Lan He Mono-, Bi-, and Triphenanthrenes from the Tubers of <i>Cremastra </i><i>a</i><i>ppendiculata</i> American Chemical Society 2006 cancer cells flavanthrinin cell line Triphenanthrene biphenanthrene monophenanthrene trihydroxy tubers Cremastra appendiculataSix newphenanthrene derivatives cirrhopetalanthin Bi Cremastra appendiculata Mono Compound compound Tuber pentahydroxy ethanolic spectroscopic methods dihydroxy hydroxy triphenanthrene 2006-06-23 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Mono_Bi_and_Triphenanthrenes_from_the_Tubers_of_i_Cremastra_i_i_a_i_i_ppendiculata_i_/3074674 Six newphenanthrene derivatives, including three monophenanthrenes (<b>1</b>−<b>3</b>), two biphenanthrenes (<b>4</b> and <b>5</b>), and a triphenanthrene (<b>6</b>), have been isolated from an ethanolic extract of the tubers of <i>Cremastra </i><i>appendiculata</i>. Using spectroscopic methods, the structures of compounds <b>1</b>−<b>6</b> were determined as 1-hydroxy-4,7-dimethoxy-1-(2-oxopropyl)-1<i>H</i>-phenanthren-2-one (<b>1</b>), 1,7-dihydroxy-4-methoxy-1-(2-oxopropyl)-1<i>H</i>-phenanthren-2-one (<b>2</b>), 2-hydroxy-4,7-dimethoxyphenanthrene (<b>3</b>), 2,7,2‘-trihydroxy-4,4‘,7‘-trimethoxy-1,1‘-biphenanthrene (<b>4</b>), 2,2‘-dihydroxy-4,7,4‘,7‘-tetramethoxy-1,1‘-biphenanthrene (<b>5</b>), and 2,7,2‘,7‘,2‘ ‘-pentahydroxy-4,4‘,4‘ ‘,7‘ ‘-tetramethoxy-1,8,1‘,1‘ ‘-triphenanthrene (<b>6</b>), respectively. Compounds <b>1</b>−<b>6</b> and two known compounds, cirrhopetalanthin (<b>7</b>) and flavanthrinin (<b>8</b>), obtained previously from this plant, were evaluated against six human cancer cells and a normal cell line.