Synthesis of Bicyclic <i>p</i>-Diiodobenzenes via Silver-Catalyzed
C<i>sp</i>-H Iodination and Ruthenium-Catalyzed Cycloaddition
Yoshihiko Yamamoto
Kozo Hattori
Hisao Nishiyama
10.1021/ja061619p.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Bicyclic_i_p_i_Diiodobenzenes_via_Silver_Catalyzed_C_i_sp_i_H_Iodination_and_Ruthenium_Catalyzed_Cycloaddition/3073819
Highly substituted iodobenzenes were efficiently and regioselectively synthesized from readily
available 1,6-diynes via two-step process consisting of silver-catalyzed C<i>sp</i>-H iodination and subsequent
ruthenium-catalyzed [2 + 2 + 2] cycloaddition of resultant iododiynes. Some of the obtained iodobenzenes
were subjected to palladium-catalyzed C−C bond-forming reactions such as Mizoroki−Heck reaction,
Sonogashira reaction, and Suzuki−Miyaura coupling, giving highly conjugated molecules.
2006-06-28 00:00:00
Mizoroki
iododiyne
cycloaddition
Suzuki
Sonogashira reaction
Iodination
Synthesi
diyne
molecule
regioselectively
iodobenzene
iodination
Bicyclic
CycloadditionHighly