Synthesis of Bicyclic <i>p</i>-Diiodobenzenes via Silver-Catalyzed C<i>sp</i>-H Iodination and Ruthenium-Catalyzed Cycloaddition Yoshihiko Yamamoto Kozo Hattori Hisao Nishiyama 10.1021/ja061619p.s001 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Bicyclic_i_p_i_Diiodobenzenes_via_Silver_Catalyzed_C_i_sp_i_H_Iodination_and_Ruthenium_Catalyzed_Cycloaddition/3073819 Highly substituted iodobenzenes were efficiently and regioselectively synthesized from readily available 1,6-diynes via two-step process consisting of silver-catalyzed C<i>sp</i>-H iodination and subsequent ruthenium-catalyzed [2 + 2 + 2] cycloaddition of resultant iododiynes. Some of the obtained iodobenzenes were subjected to palladium-catalyzed C−C bond-forming reactions such as Mizoroki−Heck reaction, Sonogashira reaction, and Suzuki−Miyaura coupling, giving highly conjugated molecules. 2006-06-28 00:00:00 Mizoroki iododiyne cycloaddition Suzuki Sonogashira reaction Iodination Synthesi diyne molecule regioselectively iodobenzene iodination Bicyclic CycloadditionHighly