Inhibition of Lysosomal Cysteine Proteases by a Series of Au(I) Complexes:  A Detailed Mechanistic Investigation Shamila S. Gunatilleke Amy M. Barrios 10.1021/jm060158f.s001 https://acs.figshare.com/articles/dataset/Inhibition_of_Lysosomal_Cysteine_Proteases_by_a_Series_of_Au_I_Complexes_A_Detailed_Mechanistic_Investigation/3073564 Complexes of gold(I) have long been used to treat rheumatoid arthritis although the precise biological targets of gold are not well understood. One intriguing therapeutic target of Au(I) is the cathepsin family of lysosomal cysteine proteases. Here, we present the inhibition of cathepsin B by a known Au(I)-based drug and a series of derivatives. The complexes investigated were reversible, competitive inhibitors with IC<sub>50</sub> values ranging from 0.3 to 250 μM, depending on the substituents around the Au(I). 2006-06-29 00:00:00 series cathepsin B Inhibition complex 250 μ M derivative Mechanistic InvestigationComplexes IC 50 values 0.3 arthritis substituent inhibition Lysosomal Cysteine Proteases cathepsin family inhibitor Series lysosomal cysteine proteases