10.1021/jo060255g.s001
Jian Wu
Jian
Wu
Zhongwu Guo
Zhongwu
Guo
Cap and Capture−Release Techniques Applied to
Solid-Phase Synthesis of Oligosaccharides
American Chemical Society
2006
CPB
resin
oligosaccharide product
carbohydrate mixture
OligosaccharidesThis paper reports
side products
carboxyl group
oligosaccharide synthesis
2006-09-01 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Cap_and_Capture_Release_Techniques_Applied_to_Solid_Phase_Synthesis_of_Oligosaccharides/3061762
This paper reports a new strategy for oligosaccharide
synthesis by combining solid-phase methods with cap and
capture−release separation techniques, using the <i>p</i>-(5-(ethoxycarbonyl)pentyloxy)benzyl group (CPB) as a tag for
the capture of desired oligosaccharides. After a complex
carbohydrate mixture was obtained by solid-phase synthesis,
the desired oligosaccharide containing a free carboxyl group
derived from CPB was attached to an amino resin. The
loaded resin was readily separated from side products by
filtration and finally treated with acid to release the pure
oligosaccharide product.