10.1021/jo0615753.s001 Thomas M. Fyles Thomas M. Fyles Chi-Wei Hu Chi-Wei Hu Horace Luong Horace Luong Solid-Phase Synthesis of Oligoester Ion Channels American Chemical Society 2006 Oligoester Ion ChannelsA synthesis ion channel candidates product oligoesters ion transport activity 2006-10-27 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Solid_Phase_Synthesis_of_Oligoester_Ion_Channels/3051334 A simple synthesis of oligoesters from TBDMS-protected-β- and THP-protected-ω-hydroxycarboxylic acids using a solid-phase synthesis protocol is reported. Procedures were optimized for the efficient production of ion channel candidates in high purity with minimal purification. The product oligoesters were evaluated for ion transport activity using a fluorescent dye/vesicle assay. Oligoesters produced by this strategy show structure-dependent activity; the most active compounds are closely comparable to previously known oligoesters, but are available at a fraction of the synthetic effort.