10.1021/jo0615753.s001
Thomas M. Fyles
Thomas M.
Fyles
Chi-Wei Hu
Chi-Wei
Hu
Horace Luong
Horace
Luong
Solid-Phase Synthesis of Oligoester Ion Channels
American Chemical Society
2006
Oligoester Ion ChannelsA
synthesis
ion channel candidates
product oligoesters
ion transport activity
2006-10-27 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Solid_Phase_Synthesis_of_Oligoester_Ion_Channels/3051334
A simple synthesis of oligoesters from TBDMS-protected-β- and THP-protected-ω-hydroxycarboxylic
acids using a solid-phase synthesis protocol is reported. Procedures were optimized for the efficient
production of ion channel candidates in high purity with minimal purification. The product oligoesters
were evaluated for ion transport activity using a fluorescent dye/vesicle assay. Oligoesters produced by
this strategy show structure-dependent activity; the most active compounds are closely comparable to
previously known oligoesters, but are available at a fraction of the synthetic effort.