Kottani, Rudresha R. R. Majjigapu, Janaki Kurchan, Alexei Majjigapu, Kavitha Gustafson, Tiffany P. Kutateladze, Andrei G. Photoinduced Signal Amplification through Controlled Externally Sensitized Fragmentation in Masked Sensitizers Addition of lithiated dithianes to diaryl ketones, potential electron-transfer sensitizers, disrupts conjugation between the two aromatic moieties, effectively masking the sensitizer. A novel photoamplification strategy is developed based on photosensitized cleavage in such adducts, where each fragmentation event releases more diaryl ketone, capable of sensitization. As a result, mass release of dithianes, triggered with a very small amount of the initiator, is observed. Such amplified release can be made contingent on a molecular recognition event, offering a promising methodology for high throughput bioanalytical applications. The concept is proved with the use of micro- and nanosized polymeric supports, including dendrimers. diaryl ketone;Masked SensitizersAddition;novel photoamplification strategy;sensitizer;diaryl ketones;throughput bioanalytical applications;Controlled Externally Sensitized Fragmentation;mass release;recognition event;Photoinduced Signal Amplification;fragmentation event releases;photosensitized cleavage;lithiated dithianes 2006-11-22
    https://acs.figshare.com/articles/journal_contribution/Photoinduced_Signal_Amplification_through_Controlled_Externally_Sensitized_Fragmentation_in_Masked_Sensitizers/3046930
10.1021/ja066692u.s001