Photoinduced Signal Amplification through Controlled Externally Sensitized
Fragmentation in Masked Sensitizers
Rudresha Kottani
Janaki R. R. Majjigapu
Alexei Kurchan
Kavitha Majjigapu
Tiffany P. Gustafson
Andrei G. Kutateladze
10.1021/ja066692u.s001
https://acs.figshare.com/articles/journal_contribution/Photoinduced_Signal_Amplification_through_Controlled_Externally_Sensitized_Fragmentation_in_Masked_Sensitizers/3046930
Addition of lithiated dithianes to diaryl ketones, potential electron-transfer sensitizers, disrupts conjugation between the two aromatic moieties, effectively masking the sensitizer. A novel photoamplification strategy is developed based on photosensitized cleavage in such adducts, where each fragmentation event releases more diaryl ketone, capable of sensitization. As a result, mass release of dithianes, triggered with a very small amount of the initiator, is observed. Such amplified release can be made contingent on a molecular recognition event, offering a promising methodology for high throughput bioanalytical applications. The concept is proved with the use of micro- and nanosized polymeric supports, including dendrimers.
2006-11-22 00:00:00
diaryl ketone
Masked SensitizersAddition
novel photoamplification strategy
sensitizer
diaryl ketones
throughput bioanalytical applications
Controlled Externally Sensitized Fragmentation
mass release
recognition event
Photoinduced Signal Amplification
fragmentation event releases
photosensitized cleavage
lithiated dithianes