Remote Desymmetrization at Near-Nanometer Group Separation Catalyzed by a Miniaturized Enzyme Mimic Chad A. Lewis Anna Chiu Michele Kubryk Jaume Balsells David Pollard Craig K. Esser Jerry Murry Robert A. Reamer Karl B. Hansen Scott J. Miller 10.1021/ja067840j.s001 https://acs.figshare.com/articles/journal_contribution/Remote_Desymmetrization_at_Near_Nanometer_Group_Separation_Catalyzed_by_a_Miniaturized_Enzyme_Mimic/3038626 The chirality of biological receptors often requires syntheses of therapeutic compounds in single enantiomer form. The field of asymmetric catalysis addresses enantioselective synthesis with chiral catalysts. Chemical differentiation of sites within molecules that are separated in space by long distances presents special challenges to chiral catalysts. As the distance between enantiotopic sites increases within a substrate, so too may the requirements for size and complexity for the catalyst. The extreme of catalyst complexity could be defined by macromolecular enzymes and their amazing capacity to effect stereospecific reactions over long distances between reactive sites and enzyme−substrate contacts. We report here a synthetic, miniaturized enzyme mimic that catalyzes a desymmetrization reaction over a very long distance. 2006-12-27 00:00:00 chiral catalysts Miniaturized Enzyme MimicThe chirality enzyme enantiotopic sites increases catalysis addresses enantioselective synthesis complexity effect stereospecific reactions