Remote Desymmetrization at Near-Nanometer Group Separation Catalyzed by
a Miniaturized Enzyme Mimic
Chad A. Lewis
Anna Chiu
Michele Kubryk
Jaume Balsells
David Pollard
Craig K. Esser
Jerry Murry
Robert A. Reamer
Karl B. Hansen
Scott J. Miller
10.1021/ja067840j.s001
https://acs.figshare.com/articles/journal_contribution/Remote_Desymmetrization_at_Near_Nanometer_Group_Separation_Catalyzed_by_a_Miniaturized_Enzyme_Mimic/3038626
The chirality of biological receptors often requires syntheses of therapeutic compounds in single enantiomer form. The field of asymmetric catalysis addresses enantioselective synthesis with chiral catalysts. Chemical differentiation of sites within molecules that are separated in space by long distances presents special challenges to chiral catalysts. As the distance between enantiotopic sites increases within a substrate, so too may the requirements for size and complexity for the catalyst. The extreme of catalyst complexity could be defined by macromolecular enzymes and their amazing capacity to effect stereospecific reactions over long distances between reactive sites and enzyme−substrate contacts. We report here a synthetic, miniaturized enzyme mimic that catalyzes a desymmetrization reaction over a very long distance.
2006-12-27 00:00:00
chiral catalysts
Miniaturized Enzyme MimicThe chirality
enzyme
enantiotopic sites increases
catalysis addresses enantioselective synthesis
complexity
effect stereospecific reactions