Ligand-Dependent Catalytic Cycle and Role of Styrene in Nickel-Catalyzed Anhydride Cross-Coupling:  Evidence for Turnover-Limiting Reductive Elimination Jeffrey B. Johnson Eric A. Bercot John M. Rowley Geoffrey W. Coates Tomislav Rovis 10.1021/ja067845g.s001 https://acs.figshare.com/articles/journal_contribution/Ligand_Dependent_Catalytic_Cycle_and_Role_of_Styrene_in_Nickel_Catalyzed_Anhydride_Cross_Coupling_Evidence_for_Turnover_Limiting_Reductive_Elimination/3020119 Results from a mechanistic study on the Ni(COD)<sub>2</sub>−bipy-catalyzed alkylation of anhydrides are consistent with turnover-limiting reductive elimination at high Et<sub>2</sub>Zn concentrations. While the presence of styrene does not affect the initial rate of alkylation, it appears to inhibit catalyst decomposition and provides higher product yield at long reaction times. In contrast, Ni(COD)<sub>2</sub>−<i><sup>i</sup></i><sup></sup>PrPHOX-catalyzed anhydride alkylation proceeds through two competing catalytic cycles differentiated by the presence of styrene. The presence of styrene in this system appears to accelerate rate-limiting oxidative addition and promotes the cycle which proceeds 4 times more rapidly and with much higher enantioselectivity than its styrene-lacking counterpart. 2007-03-07 00:00:00 Ni presence styrene proceeds 4 times Et 2Zn concentrations alkylation anhydride reaction times catalyst decomposition