Kopp, Felix Knochel, Paul Functionalization of Unprotected Uracil Derivatives Using the Halogen−Magnesium Exchange The reaction of commercially available 5-iodouracil with 2 equiv of MeMgCl in the presence of LiCl, followed by the addition of <i>i</i>-PrMgCl·LiCl, provides the corresponding trimagnesiated species, which reacts with various electrophiles to give selectively 5-functionalized uracil derivatives. This method was also successfully applied to the functionalization of 6-iodouracils including the synthesis of pharmaceutically relevant Emivirine and HEPT precursors. LiCl;ExchangeThe;functionalized;Halogen;2 equiv;Functionalization;HEPT precursors;Unprotected Uracil Derivatives;presence;pharmaceutically;functionalization;derivative;method;synthesis;electrophile;iodouracil;MeMgCl;uracil;trimagnesiated species;Emivirine 2007-04-26
    https://acs.figshare.com/articles/journal_contribution/Functionalization_of_Unprotected_Uracil_Derivatives_Using_the_Halogen_Magnesium_Exchange/3010990
10.1021/ol063136w.s001