%0 Journal Article
%A Jia, Yanxing
%A Bois-Choussy, Michèle
%A Zhu, Jieping
%D 2007
%T Synthesis of DEFG Ring of
Complestatin and Chloropeptin I: Highly
Atropdiastereoselective Macrocyclization
by Intramolecular Suzuki-Miyaura
Reaction
%U https://acs.figshare.com/articles/journal_contribution/Synthesis_of_DEFG_Ring_of_Complestatin_and_Chloropeptin_I_Highly_Atropdiastereoselective_Macrocyclization_by_Intramolecular_Suzuki_Miyaura_Reaction/3003253
%R 10.1021/ol070889p.s002
%2 https://acs.figshare.com/ndownloader/files/4704346
%K stereospecific rearrangement
%K Atropdiastereoselective Macrocyclization
%K DEFG ring 4
%K DEFG Ring
%K 3 triggers
%K Acidic treatment
%X Palladium-catalyzed intramolecular Suzuki-Miyaura reaction of linear tripeptide (23) afforded the 16-membered DEFG ring of complestatin (3)
in good yield with an excellent atropdiastereoselectivity. Acidic treatment of 3 triggers a stereospecific rearrangement leading to the corresponding
DEFG ring 4 of chloropeptin I.
%I ACS Publications