jo015632y_si_002.pdf (39.94 kB)
2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: A Privileged, Bivalent Scaffold for the Display of Nucleophilic Components
journal contribution
posted on 2001-05-23, 00:00 authored by Antonella Converso, Kristina Burow, Andreas Marzinzik, K. Barry Sharpless, M. G. FinnThe title compound, the condensation product of sulfur dichloride and 1,5-cyclooctadiene, is a reliable
acceptor of a wide variety of heteroatom nucleophiles, sometimes in reversible fashion. Optical
resolution of the core structure has been achieved and preserved in succeeding transformations.
The high reactivity and reliable stereochemical control afforded by this system illustrates the power
of neighboring-group participation by the sulfur center.