Halpenny, Genevieve M. Olmstead, Marilyn M. Mascharak, Pradip K. Incorporation of a Designed Ruthenium Nitrosyl in PolyHEMA Hydrogel and Light-Activated Delivery of NO to Myoglobin A ruthenium nitrosyl with 4-vinylpyridine (4-vpy) as one ligand, namely, [Ru(Me<sub>2</sub>bpb)(NO)(4-vpy)](BF<sub>4</sub>) (<b>1</b>), has been synthesized and structurally characterized. This diamagnetic {Ru−NO}<sup>6</sup> nitrosyl is photoactive and readily releases NO upon exposure to low-intensity (5−10 mW) UV light (quantum yield at 300 nm = 0.18). Radical-induced copolymerization of 2-hydroxyethyl methacrylate (HEMA) and ethyleneglycol dimethacrylate (EGDMA) in the presence of <b>1</b> has afforded a <b>1</b>-pHEMA, a transparent hydrogel in which <b>1</b> is covalently attached to the polymer backbone. Exposure of <b>1</b>-pHEMA to UV light (5−10 mW) results in rapid release of NO (detected by NO electrode) that can be delivered to biological targets such as myoglobin. The photoactivity of <b>1</b>-pHEMA is strictly dependent on exposure to UV light. nitrosyl;Ru;pHEMA;HEMA;EGDMA;mW;exposure;UV light;release 2007-08-06
    https://acs.figshare.com/articles/journal_contribution/Incorporation_of_a_Designed_Ruthenium_Nitrosyl_in_PolyHEMA_Hydrogel_and_Light_Activated_Delivery_of_NO_to_Myoglobin/2992585
10.1021/ic700694b.s003