%0 Journal Article %A Li, Xin %A Kyne, Robert E. %A Ovaska, Timo V. %D 2007 %T Synthesis of Seven-Membered Carbocyclic Rings via a Microwave-Assisted Tandem Oxyanionic 5-exo dig Cyclization−Claisen Rearrangement Process %U https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Seven_Membered_Carbocyclic_Rings_via_a_Microwave_Assisted_Tandem_Oxyanionic_5_i_exo_i_i_dig_i_Cyclization_Claisen_Rearrangement_Process/2990632 %R 10.1021/jo0710432.s004 %2 https://acs.figshare.com/ndownloader/files/4691380 %K trans orientation %K stereoselective %K Cyclization %K cyclohept %K Oxyanionic %K sequence %K cyclization %K Tandem %K derivative %K ProcessAppropriately %K Synthesi %K oxyanionic %K pentyn %K material %K tandem %K preference %K Carbocyclic %K Rearrangement %K alkenyl %K precursor %K exo %K β groups %K rearrangement %K terminally %X Appropriately substituted 1-alkenyl-4-pentyn-1-ol systems, readily prepared from simple starting materials, serve as useful precursors to a number of substituted cyclohept-4-enone derivatives via a microwave-assisted tandem oxyanionic 5-exo cyclization/Claisen rearrangement sequence. The reactions involving terminally substituted 4-pentyn-1-ols were found to be highly stereoselective, with the α and β groups in the final product showing a strong preference for the trans orientation. %I ACS Publications