%0 Journal Article
%A Li, Xin
%A Kyne, Robert E.
%A Ovaska, Timo V.
%D 2007
%T Synthesis of Seven-Membered Carbocyclic Rings
via a Microwave-Assisted Tandem Oxyanionic
5-exo dig Cyclization−Claisen Rearrangement
Process
%U https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Seven_Membered_Carbocyclic_Rings_via_a_Microwave_Assisted_Tandem_Oxyanionic_5_i_exo_i_i_dig_i_Cyclization_Claisen_Rearrangement_Process/2990632
%R 10.1021/jo0710432.s004
%2 https://acs.figshare.com/ndownloader/files/4691380
%K trans orientation
%K stereoselective
%K Cyclization
%K cyclohept
%K Oxyanionic
%K sequence
%K cyclization
%K Tandem
%K derivative
%K ProcessAppropriately
%K Synthesi
%K oxyanionic
%K pentyn
%K material
%K tandem
%K preference
%K Carbocyclic
%K Rearrangement
%K alkenyl
%K precursor
%K exo
%K β groups
%K rearrangement
%K terminally
%X Appropriately substituted 1-alkenyl-4-pentyn-1-ol systems,
readily prepared from simple starting materials, serve as
useful precursors to a number of substituted cyclohept-4-enone derivatives via a microwave-assisted tandem oxyanionic 5-exo cyclization/Claisen rearrangement sequence.
The reactions involving terminally substituted 4-pentyn-1-ols were found to be highly stereoselective, with the α and
β groups in the final product showing a strong preference
for the trans orientation.
%I ACS Publications