Campagna, Maurizio Trzoss, Michael Bienz, Stefan More than a Protective Group:  Synthesis and Applications of a New Chiral Silane Enantiomerically pure (−)-(<i>R</i>)- and (+)-(<i>S</i>)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilanes (MOTES-H) were synthesized from triphenylacetaldehyde in five synthetic steps and with 60% overall yield. MOTES-protected α- and β-hydroxycarbonyl compounds were used in Grignard and Diels−Alder reactions in the presence of MgBr<sub>2</sub> to afford addition products with 87−98% yield and selectivities of up to >120:1 dr. With this method, the pine beetle pheromone (−)-frontalin (67%, 98.5% ee) and naturally occurring (−)-(<i>R</i>)-octane-1,3-diol (90%, >99% ee) were synthesized. Grignard;presence;selectivitie;addition products;Application;frontalin;Protective;triphenylacetaldehyde;ee;Diel;method;Synthesi;MgBr 2;hydroxycarbonyl;compound;dr;New Chiral SilaneEnantiomerically;pheromone 2007-09-13
    https://acs.figshare.com/articles/journal_contribution/More_than_a_Protective_Group_Synthesis_and_Applications_of_a_New_Chiral_Silane/2986063
10.1021/ol071382h.s004