%0 Journal Article %A Macherla, Venkat R. %A Liu, Jehnan %A Sunga, Michelle %A White, Donald J. %A Grodberg, Jennifer %A Teisan, Sy %A Lam, Kin S. %A C. M. Potts, Barbara %D 2007 %T Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment %U https://acs.figshare.com/articles/journal_contribution/Lipoxazolidinones_A_B_and_C_Antibacterial_4_Oxazolidinones_from_a_Marine_Actinomycete_Isolated_from_a_Guam_Marine_Sediment/2983585 %R 10.1021/np0702032.s001 %2 https://acs.figshare.com/ndownloader/files/4684213 %K antibiotic linezolid %K alkylidene %K series %K strain %K SedimentMarine %K amide bond %K Cocos Lagoon %K sediment sample %K Hydrolysi %K sea water %K actinomycete %K media %K nature %K Antibacterial %K member %K Compound %K spectrum antimicrobial activity %K antibiotic pharmacophore %K genus Marinispora %K Oxazolidinone %K lipoxazolidinone %K Marine Actinomycete %K Guam %K Lipoxazolidinone %K oxazolidinone %K NPS %K Zyvox %X Marine actinomycete strain NPS008920, a member of the new genus Marinispora, was isolated from a sediment sample collected in Cocos Lagoon, Guam. In natural sea water containing media, the strain produced a series of novel 2-alkylidene-5-alkyl-4-oxazolidinones, lipoxazolidinone A (1), B (2), and C (3). Compounds 13 showed broad spectrum antimicrobial activity similar to that of the commercial antibiotic linezolid (Zyvox), a 2-oxazolidinone. Hydrolysis of the amide bond of the 4-oxazolidinone ring of 1 resulted in loss of antibacterial activity. The 2-alkylidene-4-oxazolidinone represents a new antibiotic pharmacophore and is unprecedented in nature. %I ACS Publications