%0 Journal Article
%A Macherla, Venkat R.
%A Liu, Jehnan
%A Sunga, Michelle
%A White, Donald J.
%A Grodberg, Jennifer
%A Teisan, Sy
%A Lam, Kin S.
%A C. M. Potts, Barbara
%D 2007
%T Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment
%U https://acs.figshare.com/articles/journal_contribution/Lipoxazolidinones_A_B_and_C_Antibacterial_4_Oxazolidinones_from_a_Marine_Actinomycete_Isolated_from_a_Guam_Marine_Sediment/2983585
%R 10.1021/np0702032.s001
%2 https://acs.figshare.com/ndownloader/files/4684213
%K antibiotic linezolid
%K alkylidene
%K series
%K strain
%K SedimentMarine
%K amide bond
%K Cocos Lagoon
%K sediment sample
%K Hydrolysi
%K sea water
%K actinomycete
%K media
%K nature
%K Antibacterial
%K member
%K Compound
%K spectrum antimicrobial activity
%K antibiotic pharmacophore
%K genus Marinispora
%K Oxazolidinone
%K lipoxazolidinone
%K Marine Actinomycete
%K Guam
%K Lipoxazolidinone
%K oxazolidinone
%K NPS
%K Zyvox
%X Marine actinomycete strain NPS008920, a member of the new genus Marinispora, was isolated from a sediment sample collected in Cocos Lagoon, Guam. In natural sea water containing media, the strain produced a series of novel 2-alkylidene-5-alkyl-4-oxazolidinones, lipoxazolidinone A (1), B (2), and C (3). Compounds 1–3 showed broad spectrum antimicrobial activity similar to that of the commercial antibiotic linezolid (Zyvox), a 2-oxazolidinone. Hydrolysis of the amide bond of the 4-oxazolidinone ring of 1 resulted in loss of antibacterial activity. The 2-alkylidene-4-oxazolidinone represents a new antibiotic pharmacophore and is unprecedented in nature.
%I ACS Publications