Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment Venkat R. Macherla Jehnan Liu Michelle Sunga Donald J. White Jennifer Grodberg Sy Teisan Kin S. Lam Barbara C. M. Potts 10.1021/np0702032.s001 https://acs.figshare.com/articles/journal_contribution/Lipoxazolidinones_A_B_and_C_Antibacterial_4_Oxazolidinones_from_a_Marine_Actinomycete_Isolated_from_a_Guam_Marine_Sediment/2983585 Marine actinomycete strain NPS008920, a member of the new genus <i>Marinispora</i>, was isolated from a sediment sample collected in Cocos Lagoon, Guam. In natural sea water containing media, the strain produced a series of novel 2-alkylidene-5-alkyl-4-oxazolidinones, lipoxazolidinone A (<b>1</b>), B (<b>2</b>), and C (<b>3</b>). Compounds <b>1</b>–<b>3</b> showed broad spectrum antimicrobial activity similar to that of the commercial antibiotic linezolid (Zyvox), a 2-oxazolidinone. Hydrolysis of the amide bond of the 4-oxazolidinone ring of <b>1</b> resulted in loss of antibacterial activity. The 2-alkylidene-4-oxazolidinone represents a new antibiotic pharmacophore and is unprecedented in nature. 2007-09-28 00:00:00 antibiotic linezolid alkylidene series strain SedimentMarine amide bond Cocos Lagoon sediment sample Hydrolysi sea water actinomycete media nature Antibacterial member Compound spectrum antimicrobial activity antibiotic pharmacophore genus Marinispora Oxazolidinone lipoxazolidinone Marine Actinomycete Guam Lipoxazolidinone oxazolidinone NPS Zyvox