Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment
Venkat R. Macherla
Jehnan Liu
Michelle Sunga
Donald J. White
Jennifer Grodberg
Sy Teisan
Kin S. Lam
Barbara C. M. Potts
10.1021/np0702032.s001
https://acs.figshare.com/articles/journal_contribution/Lipoxazolidinones_A_B_and_C_Antibacterial_4_Oxazolidinones_from_a_Marine_Actinomycete_Isolated_from_a_Guam_Marine_Sediment/2983585
Marine actinomycete strain NPS008920, a member of the new genus <i>Marinispora</i>, was isolated from a sediment sample collected in Cocos Lagoon, Guam. In natural sea water containing media, the strain produced a series of novel 2-alkylidene-5-alkyl-4-oxazolidinones, lipoxazolidinone A (<b>1</b>), B (<b>2</b>), and C (<b>3</b>). Compounds <b>1</b>–<b>3</b> showed broad spectrum antimicrobial activity similar to that of the commercial antibiotic linezolid (Zyvox), a 2-oxazolidinone. Hydrolysis of the amide bond of the 4-oxazolidinone ring of <b>1</b> resulted in loss of antibacterial activity. The 2-alkylidene-4-oxazolidinone represents a new antibiotic pharmacophore and is unprecedented in nature.
2007-09-28 00:00:00
antibiotic linezolid
alkylidene
series
strain
SedimentMarine
amide bond
Cocos Lagoon
sediment sample
Hydrolysi
sea water
actinomycete
media
nature
Antibacterial
member
Compound
spectrum antimicrobial activity
antibiotic pharmacophore
genus Marinispora
Oxazolidinone
lipoxazolidinone
Marine Actinomycete
Guam
Lipoxazolidinone
oxazolidinone
NPS
Zyvox