10.1021/ja077457u.s006 Ngoc T. Vo Ngoc T. Vo Robert D. M. Pace Robert D. M. Pace Fionn O'Har Fionn O'Har Matthew J. Gaunt Matthew J. Gaunt An Enantioselective Organocatalytic Oxidative Dearomatization Strategy American Chemical Society 2008 exploitable orthogonal functionality intramolecular Michael addition array chemical synthesis decalin structure oxidative dearomatization phenol nonracemic desymmetrizing Enantioselective Organocatalytic Oxidative Dearomatization Strategy molecule enantioselective strategy stereogenic centers complexity 2008-01-16 00:00:00 Dataset https://acs.figshare.com/articles/dataset/An_Enantioselective_Organocatalytic_Oxidative_Dearomatization_Strategy/2963086 We have developed a catalytic enantioselective strategy for chemical synthesis wherein flat aromatic molecules are directly converted to complex nonracemic molecular architectures. The process involves oxidative dearomatization of substituted phenols followed by a desymmetrizing secondary amine-catalyzed asymmetric intramolecular Michael addition and reveals a decalin structure, formed with exquisite control of three new stereogenic centers and an array of exploitable orthogonal functionality, directly from a flat molecule that is devoid of architectural complexity.