Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants José C. Aponte Abraham J. Vaisberg Rosario Rojas Luz Caviedes Walter H. Lewis Gerardo Lamas César Sarasara Robert H. Gilman Gerald B. Hammond 10.1021/np070560c.s001 https://acs.figshare.com/articles/journal_contribution/Isolation_of_Cytotoxic_Metabolites_from_Targeted_Peruvian_Amazonian_Medicinal_Plants/2961193 The antiproliferative bioassay-guided fractionation of five Peruvian plants, <i>Doliocarpus dentatus</i>, <i>Picramnia sellowii</i>, <i>Strychnos mitscherlichii, Iryanthera juruensis</i>, and <i>Croton alnifolius</i>, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (<b>1</b>), nataloe-emodin (<b>2</b>), bisnordihydrotoxyferine (<b>4</b>), 2′,4′-dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (<b>5</b>), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (<b>6</b>) and 12-<i>O</i>-tetradecanoylphorbol-13-acetate (<b>7</b>), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against <i>Mycobacterium tuberculosis</i> is also reported. 2008-01-25 00:00:00 PlantsThe Mycobacterium tuberculosis antiproliferative fractionation acid Amazonian Targeted nontumorigenic cell lines investigation identification dihydroxy Doliocarpus dentatus Iryanthera juruensis tumor cell lines Isolation cytotoxic constituents betulinic Cytotoxic Metabolites Medicinal Picramnia sellowii Peruvian plants bisnordihydrotoxyferine Strychnos mitscherlichii isolation Croton alnifolius