10.1021/jo702130a.s003
José Luis García Ruano
José
Luis García Ruano
Teresa de Haro
Teresa de
Haro
Rajinder Singh
Rajinder
Singh
M. Belén Cid
M. Belén
Cid
An Efficient Method for the Synthesis of
Nitropiperidones
American Chemical Society
2008
esters
tolylsulfinyl
hydrolysis
Michael addition
sulfinyl group
cyclization
strategy
Efficient Method
synthesis
amines
nitropiperidone
Nitropiperidone
nitroamine
purification
Synthesi
procedure
2008-02-01 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/An_Efficient_Method_for_the_Synthesis_of_Nitropiperidones/2960257
A three step efficient strategy for the synthesis of substituted
5-nitropiperidones in high de, employing Michael addition
of N-<i>p</i>-tolylsulfinyl β-nitroamines to α,β-unsaturated esters,
hydrolysis of the sulfinyl group, and cyclization of the
resulting free amines, has been developed. A very simple
experimental procedure involving mild conditions and only
one chromatographic purification are the main features of
the process.