10.1021/jo702130a.s003 José Luis García Ruano José Luis García Ruano Teresa de Haro Teresa de Haro Rajinder Singh Rajinder Singh M. Belén Cid M. Belén Cid An Efficient Method for the Synthesis of Nitropiperidones American Chemical Society 2008 esters tolylsulfinyl hydrolysis Michael addition sulfinyl group cyclization strategy Efficient Method synthesis amines nitropiperidone Nitropiperidone nitroamine purification Synthesi procedure 2008-02-01 00:00:00 Dataset https://acs.figshare.com/articles/dataset/An_Efficient_Method_for_the_Synthesis_of_Nitropiperidones/2960257 A three step efficient strategy for the synthesis of substituted 5-nitropiperidones in high de, employing Michael addition of N-<i>p</i>-tolylsulfinyl β-nitroamines to α,β-unsaturated esters, hydrolysis of the sulfinyl group, and cyclization of the resulting free amines, has been developed. A very simple experimental procedure involving mild conditions and only one chromatographic purification are the main features of the process.