A Controlled and Reproducible Pathway to Dye-Tagged,
Encapsulated Silver Nanoparticles as Substrates for SERS
Multiplexing
Leif O. Brown
Stephen K. Doorn
10.1021/la703853e.s002
https://acs.figshare.com/articles/journal_contribution/A_Controlled_and_Reproducible_Pathway_to_Dye_Tagged_Encapsulated_Silver_Nanoparticles_as_Substrates_for_SERS_Multiplexing/2951095
Silver nanoparticles tagged with dyes and encapsulated within a silica layer, offer a convenient potential substrate
for performing multiplexed surface-enhanced Raman scattering (SERS) analysis. In contrast to our earlier work with
gold particles, aggregation of silver particles is found to be mostly independent of dye addition, allowing for a
reproducible preparation in which aggregation is actively induced by the addition of NaCl. Separating the aggregation
step eliminates competitive binding between the dyes and silica-coating reagents, enabling the efficient use of a wide
variety of weakly binding dyes to conveniently generate robust, high-intensity SERS substrates at a variety of excitation
frequencies.
2008-03-18 00:00:00
gold particles
variety
silver particles
Reproducible Pathway
excitation frequencies
SERS substrates
SERS MultiplexingSilver nanoparticles
binding dyes
dye addition
Encapsulated Silver Nanoparticles
aggregation step
silica layer