10.1021/ja710922h.s002 Joshua D. Sieber Joshua D. Sieber James P. Morken James P. Morken Asymmetric Ni-Catalyzed Conjugate Allylation of Activated Enones American Chemical Society 2008 benzylidene site dialkylidene ketones dialkylidene ketone substrate reductive elimination nonsymmetric substrates chiral ligand 14 allylboronic acid pinacol ester Enantioselectivities range 2008-04-09 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Asymmetric_Ni_Catalyzed_Conjugate_Allylation_of_Activated_Enones/2945758 The nickel-catalyzed enantioselective addition of allylboronic acid pinacol ester, allylB(pin), is described. This reaction is highly effective with dialkylidene ketones and favors the allylation of the benzylidene site in nonsymmetric substrates. The reaction appears to proceed by conversion of the dialkylidene ketone substrate to an unsaturated π-allyl complex (<b>I</b>), followed by reductive elimination. Enantioselectivities range from 91 to 94% ee for a range of substrates when chiral ligand <b>14</b> is employed.