Synthesis of (2-Oxoindolin-3-ylidene)methyl Acetates Involving a C−H Functionalization Process
Shi Tang
Peng Peng
Zhi-Qiang Wang
Bo-Xiao Tang
Chen-Liang Deng
Jin-Heng Li
Ping Zhong
Nai-Xing Wang
10.1021/ol8006315.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_2_Oxoindolin_3_ylidene_methyl_Acetates_Involving_a_C_H_Functionalization_Process/2942164
A novel palladium-catalyzed oxidative C−H functionalization protocol for the synthesis of (2-oxoindolin-3-ylidene)methyl acetates has been developed. In the presence of Pd(OAc)<sub>2</sub> and PhI(OAc)<sub>2</sub>, a variety of <i>N</i>-arylpropiolamides underwent the C−H functionalization reaction with acids to afford the corresponding (<i>E</i>)-(2-oxoindolin-3-ylidene)methyl acetates selectively in moderate to excellent yields.
2008-05-01 00:00:00
PhI
presence
acetate
Oxoindolin
Pd
Functionalization
acid
variety
oxoindolin
functionalization
synthesis
yield
oxidative
Acetate
Synthesi