Gøgsig, Thomas M. Søbjerg, Lina S. Lindhardt, Anders T. Jensen, Kim L. Skrydstrup, Troels Direct Vinylation and Difluorovinylation of Arylboronic Acids Using Vinyl- and 2,2-Difluorovinyl Tosylates via the Suzuki−Miyaura Cross Coupling General reaction conditions were developed for the Pd(0)-catalyzed Suzuki−Miyaura coupling reaction of aryl boronic acids with a simple electrophilic vinylation reagent, vinyl tosylate, providing access to styrene derivatives in good yields. The easily accessible vinyl tosylate represents a stable and less toxic alternative to the vinyl halides and the triflate/nonaflate derivatives. Furthermore, this methodology was expanded to provide a facile and straightforward approach for the introduction of a <i>gem</i>-difluorovinyl substituent onto an aromatic ring using the similar and also readily available 2,2-difluorovinyl tosylate as the electrophilic complement. Suzuki;electrophilic vinylation reagent;derivative;aryl boronic acids;vinyl tosylate;General reaction conditions 2008-05-02
    https://acs.figshare.com/articles/journal_contribution/Direct_Vinylation_and_Difluorovinylation_of_Arylboronic_Acids_Using_Vinyl_and_2_2_Difluorovinyl_Tosylates_via_the_Suzuki_Miyaura_Cross_Coupling/2941081
10.1021/jo7027097.s002