%0 Journal Article
%A Leijondahl, Karin
%A Borén, Linnéa
%A Braun, Roland
%A Bäckvall, Jan-E.
%D 2008
%T Enantiopure 1,5-Diols from Dynamic Kinetic Asymmetric Transformation. Useful Synthetic Intermediates for the Preparation of Chiral Heterocycles
%U https://acs.figshare.com/articles/journal_contribution/Enantiopure_1_5_Diols_from_Dynamic_Kinetic_Asymmetric_Transformation_Useful_Synthetic_Intermediates_for_the_Preparation_of_Chiral_Heterocycles/2939101
%R 10.1021/ol800468h.s001
%2 https://acs.figshare.com/ndownloader/files/4637788
%K morpholine
%K DYKAT
%K presence
%K series
%K Intermediate
%K Chiral Heterocycles Dynamic
%K piperidine
%K enantiopure
%K Diol
%K diacetate
%K Pseudomonas
%K transformation
%K Dynamic Kinetic Asymmetric Transformation
%K diol
%K Preparation
%K Enantiopure
%K Candida antarctica lipase B
%K cepacia
%K intermediate
%K CALB
%K II
%K Useful
%K disubstituted
%K synthese
%K ruthenium catalyst 4.
%X Dynamic kinetic asymmetric transformation (DYKAT) of a series of 1,5-diols has been performed in the presence of Candida antarctica lipase B (CALB), Pseudomonas cepacia lipase II (PS-C II), and ruthenium catalyst 4. The resulting optically pure 1,5-diacetates are useful synthetic intermediates, which was demonstrated by the syntheses of both an enantiopure 2,6-disubstituted piperidine and an enantiopure 3,5-disubstituted morpholine.
%I ACS Publications