%0 Journal Article %A Leijondahl, Karin %A Borén, Linnéa %A Braun, Roland %A Bäckvall, Jan-E. %D 2008 %T Enantiopure 1,5-Diols from Dynamic Kinetic Asymmetric Transformation. Useful Synthetic Intermediates for the Preparation of Chiral Heterocycles %U https://acs.figshare.com/articles/journal_contribution/Enantiopure_1_5_Diols_from_Dynamic_Kinetic_Asymmetric_Transformation_Useful_Synthetic_Intermediates_for_the_Preparation_of_Chiral_Heterocycles/2939101 %R 10.1021/ol800468h.s001 %2 https://acs.figshare.com/ndownloader/files/4637788 %K morpholine %K DYKAT %K presence %K series %K Intermediate %K Chiral Heterocycles Dynamic %K piperidine %K enantiopure %K Diol %K diacetate %K Pseudomonas %K transformation %K Dynamic Kinetic Asymmetric Transformation %K diol %K Preparation %K Enantiopure %K Candida antarctica lipase B %K cepacia %K intermediate %K CALB %K II %K Useful %K disubstituted %K synthese %K ruthenium catalyst 4. %X Dynamic kinetic asymmetric transformation (DYKAT) of a series of 1,5-diols has been performed in the presence of Candida antarctica lipase B (CALB), Pseudomonas cepacia lipase II (PS-C II), and ruthenium catalyst 4. The resulting optically pure 1,5-diacetates are useful synthetic intermediates, which was demonstrated by the syntheses of both an enantiopure 2,6-disubstituted piperidine and an enantiopure 3,5-disubstituted morpholine. %I ACS Publications