Salomone, Antonio Capriati, Vito Florio, Saverio Luisi, Renzo Michael Addition of Ortho-Lithiated Aryloxiranes to α,β-Unsaturated Malonates: Synthesis of Tetrahydroindenofuranones A short and efficient synthesis of tetrahydroindenofuranones based on the Michael addition of ortho-lithiated aryloxiranes to alkylidene malonates followed by the nucleophilic oxirane ring-opening and subsequent lactonization is described. The methodology has been applied to the synthesis of a structural analogue of epipodophyllotoxins. Michael Addition;alkylidene malonates;analogue;Aryloxirane;Michael addition;methodology;oxirane;synthesis;Tetrahydroindenofuranone;epipodophyllotoxin;nucleophilic;lactonization;Malonate;tetrahydroindenofuranone;Synthesi;aryloxirane;Unsaturated 2008-05-15
    https://acs.figshare.com/articles/journal_contribution/Michael_Addition_of_Ortho_Lithiated_Aryloxiranes_to_Unsaturated_Malonates_Synthesis_of_Tetrahydroindenofuranones/2939080
10.1021/ol800437s.s002