Michael Addition of Ortho-Lithiated Aryloxiranes to α,β-Unsaturated Malonates: Synthesis of Tetrahydroindenofuranones Antonio Salomone Vito Capriati Saverio Florio Renzo Luisi 10.1021/ol800437s.s002 https://acs.figshare.com/articles/journal_contribution/Michael_Addition_of_Ortho_Lithiated_Aryloxiranes_to_Unsaturated_Malonates_Synthesis_of_Tetrahydroindenofuranones/2939080 A short and efficient synthesis of tetrahydroindenofuranones based on the Michael addition of ortho-lithiated aryloxiranes to alkylidene malonates followed by the nucleophilic oxirane ring-opening and subsequent lactonization is described. The methodology has been applied to the synthesis of a structural analogue of epipodophyllotoxins. 2008-05-15 00:00:00 Michael Addition alkylidene malonates analogue Aryloxirane Michael addition methodology oxirane synthesis Tetrahydroindenofuranone epipodophyllotoxin nucleophilic lactonization Malonate tetrahydroindenofuranone Synthesi aryloxirane Unsaturated