Fowler, Sarah A. Stacy, Danielle M. Blackwell, Helen E. Design and Synthesis of Macrocyclic Peptomers as Mimics of a Quorum Sensing Signal from <i>Staphylococcus aureus</i> We report the design and synthesis of macrocyclic peptide-peptoid hybrids (peptomers) as analogs of autoinducing peptide I (AIP-I) from Staphylococcus aureus. Our solid-phase synthetic route includes efficient microwave-assisted reactions and a tandem macrocyclization-cleavage step, and we demonstrate its compatibility with parallel synthesis through the generation of a focused peptomer library. One of the peptomers was capable of stimulating biofilm formation in S. aureus, a phenotype linked to AIP-I receptor (AgrC-I) inhibition. Staphylococcus aureus;synthesis;peptomer 2008-06-19
    https://acs.figshare.com/articles/journal_contribution/Design_and_Synthesis_of_Macrocyclic_Peptomers_as_Mimics_of_a_Quorum_Sensing_Signal_from_i_Staphylococcus_aureus_i_/2933197
10.1021/ol800908h.s001