%0 Journal Article %A Fowler, Sarah A. %A Stacy, Danielle M. %A Blackwell, Helen E. %D 2008 %T Design and Synthesis of Macrocyclic Peptomers as Mimics of a Quorum Sensing Signal from Staphylococcus aureus %U https://acs.figshare.com/articles/journal_contribution/Design_and_Synthesis_of_Macrocyclic_Peptomers_as_Mimics_of_a_Quorum_Sensing_Signal_from_i_Staphylococcus_aureus_i_/2933197 %R 10.1021/ol800908h.s001 %2 https://acs.figshare.com/ndownloader/files/4631782 %K Staphylococcus aureus %K synthesis %K peptomer %X We report the design and synthesis of macrocyclic peptide-peptoid hybrids (peptomers) as analogs of autoinducing peptide I (AIP-I) from Staphylococcus aureus. Our solid-phase synthetic route includes efficient microwave-assisted reactions and a tandem macrocyclization-cleavage step, and we demonstrate its compatibility with parallel synthesis through the generation of a focused peptomer library. One of the peptomers was capable of stimulating biofilm formation in S. aureus, a phenotype linked to AIP-I receptor (AgrC-I) inhibition. %I ACS Publications