Sonogashira Couplings of Aryl Bromides: Room Temperature, Water Only, No Copper
Bruce H. Lipshutz
David W. Chung
Brian Rich
10.1021/ol801471f.s001
https://acs.figshare.com/articles/journal_contribution/Sonogashira_Couplings_of_Aryl_Bromides_Room_Temperature_Water_Only_No_Copper/2916646
Cross-coupling reactions between lipophilic terminal alkynes and aryl bromides can be catalyzed by ligated Pd, in the absence of copper, in pure water at ambient temperatures. Small amounts of the nonionic amphiphile PTS assist by virtue of nanometer micelles formed spontaneously in an aqueous medium.
2008-09-04 00:00:00
Aryl Bromides
amphiphile PTS
lipophilic terminal alkynes
absence
ligated Pd
nanometer micelles
Sonogashira Couplings
ambient temperatures
medium
Small amounts
virtue
aryl bromides
Room Temperature