Sonogashira Couplings of Aryl Bromides: Room Temperature, Water Only, No Copper Bruce H. Lipshutz David W. Chung Brian Rich 10.1021/ol801471f.s001 https://acs.figshare.com/articles/journal_contribution/Sonogashira_Couplings_of_Aryl_Bromides_Room_Temperature_Water_Only_No_Copper/2916646 Cross-coupling reactions between lipophilic terminal alkynes and aryl bromides can be catalyzed by ligated Pd, in the absence of copper, in pure water at ambient temperatures. Small amounts of the nonionic amphiphile PTS assist by virtue of nanometer micelles formed spontaneously in an aqueous medium. 2008-09-04 00:00:00 Aryl Bromides amphiphile PTS lipophilic terminal alkynes absence ligated Pd nanometer micelles Sonogashira Couplings ambient temperatures medium Small amounts virtue aryl bromides Room Temperature