10.1021/jo801831c.s001
Dahong Jiang
Dahong
Jiang
Yuanwei Chen
Yuanwei
Chen
Reduction of Δ<sup>2</sup>-Isoxazolines to β-Hydroxy Ketones with Iron and Ammonium Chloride as Reducing Agent
American Chemical Society
2008
Ammonium Chloride
water results
ammonium chloride
chemoselective protocol
ketone
hydroxy
2008-11-21 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Reduction_of_sup_2_sup_Isoxazolines_to_Hydroxy_Ketones_with_Iron_and_Ammonium_Chloride_as_Reducing_Agent/2898349
A detailed study of a procedure for the selective reduction of Δ<sup>2</sup>-isoxazolines to the corresponding β-hydroxy ketones is reported. The use of iron and ammonium chloride as the reducing agent in the presence of water results in a facile and chemoselective protocol for the preparation of β-hydroxy ketones, including the conjugated β-hydroxy ketones.