Petrova, Krastina V. Mohr, Justin T. Stoltz, Brian M. Enantioselective Total Synthesis of (+)-Cassiol An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd<sub>2</sub>(pmdba)<sub>3</sub> and enantiopure <i>t</i>-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early stage. The overall synthetic strategy involves a convergent late-stage coupling of two fragments. The synthesis features a longest linear sequence of eight steps. Enantioselective;sequence;enantioconvergent;convergent;catalyze;Pd;strategy;enantioselective;ligand;quaternary carbon stereocenter;decarboxylative;Cassiol;alkylation;fragment;synthesis features;cassiol;enantiopure;Synthesi 2009-01-15
    https://acs.figshare.com/articles/journal_contribution/Enantioselective_Total_Synthesis_of_Cassiol/2885437
10.1021/ol802410t.s001