%0 Journal Article %A Yar, Muhammad %A McGarrigle, Eoghan M. %A Aggarwal, Varinder K. %D 2009 %T Bromoethylsulfonium SaltA More Effective Annulation Agent for the Synthesis of 6- and 7-Membered 1,4-Heterocyclic Compounds %U https://acs.figshare.com/articles/journal_contribution/Bromoethylsulfonium_Salt_A_More_Effective_Annulation_Agent_for_the_Synthesis_of_6_and_7_Membered_1_4_Heterocyclic_Compounds/2885422 %R 10.1021/ol8023727.s002 %2 https://acs.figshare.com/ndownloader/files/4583335 %K annulation %K Effective Annulation Agent %K generation %K aminoalcohol %K benzoxazepine %K nitrogen substituents %K diamine %K Compound %K thiol %K method %K Synthesi %K benzodiazepines %K vinyl sulfonium salt %K Heterocyclic %K yield %K compound %K Membered %K piperazine %K thiomorpholine %K Bromoethylsulfonium %K heterocyclic %K morpholine %K bromoethylsulfonium salt %K procedure %X Reaction of bromoethylsulfonium salt with 1,2-/1,3-aminoalcohols gave six- and seven-membered rings in good-to-excellent yields. The reactions proceed through generation of a vinyl sulfonium salt followed by annulation to give 1,4-heterocyclic compounds such as morpholines and benzoxazepines in a simple procedure. The method accommodates a range of nitrogen substituents and the amino alcohol can be substituted by amino thiols and diamines to give thiomorpholines, piperazines and benzodiazepines. %I ACS Publications