Keck, Gary E. Poudel, Yam B. Welch, Dennie S. Kraft, Matthew B. Truong, Anh P. Stephens, Jeffrey C. Kedei, Noemi Lewin, Nancy E. Blumberg, Peter M. Substitution on the A-Ring Confers to Bryopyran Analogues the Unique Biological Activity Characteristic of Bryostatins and Distinct From That of the Phorbol Esters A close structural analogue of bryostatin 1, which differs from bryostatin 1 only by the absence of the C<sub>30</sub> carbomethoxy group (on the C<sub>13</sub> enoate of the B-ring), has been prepared by total synthesis. Biological assays reveal a crucial role for substitution in the bryostatin 1 A-ring in conferring those responses which are characteristic of bryostatin 1 and distinct from those observed with PMA. PMA;C 13 enoate;C 30 carbomethoxy group;bryostatin 1 2009-02-05
    https://acs.figshare.com/articles/journal_contribution/Substitution_on_the_A_Ring_Confers_to_Bryopyran_Analogues_the_Unique_Biological_Activity_Characteristic_of_Bryostatins_and_Distinct_From_That_of_the_Phorbol_Esters/2880841
10.1021/ol8027253.s001